Original paper
Total Enzyme Syntheses of Napyradiomycins A1 and B1
Volume: 140, Issue: 51, Pages: 17840 - 17845
Published: Dec 10, 2018
Abstract
The biosynthetic route to the napyradiomycin family of bacterial meroterpenoids has been fully described 32 years following their original isolation and 11 years after their gene cluster discovery. The antimicrobial and cytotoxic natural products napyradiomycins A1 and B1 are produced using three organic substrates (1,3,6,8-tetrahydroxynaphthalene, dimethylallyl pyrophosphate, and geranyl pyrophosphate), and catalysis via five enzymes: two...
Paper Details
Title
Total Enzyme Syntheses of Napyradiomycins A1 and B1
Published Date
Dec 10, 2018
Volume
140
Issue
51
Pages
17840 - 17845