THU0038 Increase of circulating memory b cells after glucocorticoid-induced remission identifies patients at risk of igg4-related disease relapse

Background

IgG4-related disease (IgG4-RD) is relapsing-remitting systemic fibro-inflammatory condition characterised by elevated serum IgG4 concentration and by tumor-like lesions[.¹ Glucocorticoids represent the treatment of choice to induce IgG4-RD remission but relapses occur in almost 50% of patients at two years.² Several evidences suggest that B cells are central to the pathogenesis of IgG4-RD, the most...