Derivative (finance)

Organic chemistry

Fungus

Escherichia coli

Stereochemistry

Biology

Microbiology

Plant use of endophytic fungi in defense

Gene

Financial economics

Economics

Chemistry

Indene

Pathogen

Klebsiella pneumoniae

Isolation (microbiology)

Ethyl acetate

Botany

Antimicrobial

Biochemistry

Natural Product Research

As part of the search for naturally derived secondary metabolites, a novel indene derivative, compound 1, together with nine known metabolites (2-10) have been purified from an ethyl acetate extract of the plant-associated fungus Aspergillus flavipes Y-62, isolated from Suaeda glauca (Bunge) Bunge which was collected along Zhoushan coast, Zhejiang province, East China. The structure of the new compound 1 was elucidated by extensive use of spectroscopic techniques like 1D, 2D NMR, and HR-TOF-MS, while the known metabolites were established based on both spectral methods as well as by comparison with the previous literature. Compound 1 exhibited antimicrobial activities against the gram-negative pathogen Pseudomonas aeruginosa and Klebsiella pneumoniae with equal MIC values of 32 µg/ml.

Isolation and structure determination of a new indene derivative from endophytic fungus <i>Aspergillus flavipes</i> Y-62

Isolation and structure determination of a new indene derivative from endophytic fungus Aspergillus flavipes Y-62