PCSK9 inhibitors: clinical evidence and implementation

Volume: 16, Issue: 3, Pages: 155 - 165
Published: Nov 12, 2018
Abstract
The gene encoding PCSK9 was first identified and linked to the phenotype of familial hypercholesterolaemia approximately 15 years ago. Soon after, studies uncovered the role of PCSK9 in the regulation of LDL-receptor recycling and identified loss-of-function variants of PCSK9 that were associated with low circulating levels of LDL cholesterol (LDL-C) and a reduced risk of coronary artery disease. With amazing rapidity, monoclonal antibodies...
Paper Details
Title
PCSK9 inhibitors: clinical evidence and implementation
Published Date
Nov 12, 2018
Volume
16
Issue
3
Pages
155 - 165
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