To summarize studies investigating ethnical and racial differences in atopic dermatitis (AD) epidemiology , clinical features , and skin and blood phenotypes. PubMed literature review (years 2000-2018). Articles discussing primarily human disease. Higher overall rates of AD were found in Africa and Oceania as opposed to India and Northern and Eastern Europe. In the United States, AD prevalence was found to be higher in African American (19.3%) compared with European American (16.1%) children. Although several studies have consistently found FLG loss-of-function mutations in up to 50% of European and 27% of Asian patients with AD, FLG mutations were 6 times less common in African American than in European American patients, even in patients with severe AD. Thus, FLG mutations seem to play less a pathogenic role in patients of African origin than in individuals of European or Asian ancestry. The immune phenotype of all ethnic groups was characterized by strong T H 2 activation, but important differences in immune polarization exist among the different ethnicities. Asian patients with AD had stronger T H 17/T H 22 activation than African American and European American patients with AD, whereas African American patients had the highest serum IgE levels among all groups, while largely lacking T H 1 and T H 17 activation. AD is a heterogeneous disease that has differences among various ethnic and racial groups, which might be important for the development of future, targeted treatments and for personalized medicine approaches.