Review paper
BRD4 and Cancer: going beyond transcriptional regulation
Abstract
BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes expression regulation. Inhibition of BRD4 shortcuts the communication between SEs and target promoters with a subsequent cell-specific repression of oncogenes to which cancer cells are addicted and cell death. To date, this is the most credited mechanism of action of BET...
Paper Details
Title
BRD4 and Cancer: going beyond transcriptional regulation
Published Date
Nov 22, 2018
Journal
Volume
17
Issue
1