T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Abstract
In the small intestine, a niche of accessory cell types supports the generation of mature epithelial cell types from intestinal stem cells (ISCs). It is unclear, however, if and how immune cells in the niche affect ISC fate or the balance between self-renewal and differentiation. Here, we use single-cell RNA sequencing (scRNA-seq) to identify MHC class II (MHCII) machinery enrichment in two subsets of Lgr5+ ISCs. We show that MHCII+ Lgr5+ ISCs...
Paper Details
Title
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Published Date
Nov 15, 2018
Journal
Volume
175
Issue
5
Pages
1307 - 1320
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