Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives
Abstract
Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. Its constituent protein β-tubulin has been a common drug target for various diseases including cancer. Colchicine has been used to treat gout, but it has also been an investigational anticancer agent with a known antimitotic effect on cells. However, the use of colchicine as well as many of its derivatives in long-term treatment is hampered by...
Paper Details
Title
Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives
Published Date
Nov 1, 2018
Journal
Volume
7
Issue
11
Pages
192 - 192
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Notes
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