A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction

Volume: 39, Issue: 12, Pages: 1008 - 1020
Published: Dec 1, 2018
Abstract
Cocaine can induce pathological A2AR-D2R-Sigma1R complexes in nucleus accumbens. These A2AR-D2R-Sigma1R complexes can put a brake on D2R signaling. These pathological A2AR-D2R-Sigma1R complexes are proposed to produce cocaine addiction. Future pharmacotherapy should target accumbal pathological A2AR-D2R-Sigma1R complexes by using interface-interfering peptides and heterobivalent compounds. The concept of allosteric receptor–receptor interactions...
Paper Details
Title
A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction
Published Date
Dec 1, 2018
Volume
39
Issue
12
Pages
1008 - 1020
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