A2AR-D2R Heteroreceptor Complexes in Cocaine Reward and Addiction

Cocaine can induce pathological A2AR-D2R-Sigma1R complexes in nucleus accumbens. These A2AR-D2R-Sigma1R complexes can put a brake on D2R signaling. These pathological A2AR-D2R-Sigma1R complexes are proposed to produce cocaine addiction. Future pharmacotherapy should target accumbal pathological A2AR-D2R-Sigma1R complexes by using interface-interfering peptides and heterobivalent compounds. The concept of allosteric receptor–receptor interactions...