Modeling the acute effects of exercise on insulin kinetics in type 1 diabetes

Our objective is to develop a physiology-based model of insulin kinetics to understand how exercise alters insulin concentrations in those with type 1 diabetes (T1D). We reveal the relationship between the insulin absorption rate ( $k^I_a ) from subcutaneous tissue, the insulin delivery rate ( k^I_d ) to skeletal muscle, and two physiological parameters that characterize the tissue: the perfusion rate (Q) and the capillary permeability...