Radiotherapy induces responses of lung cancer to CTLA-4 blockade

Volume: 24, Issue: 12, Pages: 1845 - 1851
Published: Nov 5, 2018
Abstract
Focal radiation therapy enhances systemic responses to anti-CTLA-4 antibodies in preclinical studies and in some patients with melanoma1-3, but its efficacy in inducing systemic responses (abscopal responses) against tumors unresponsive to CTLA-4 blockade remained uncertain. Radiation therapy promotes the activation of anti-tumor T cells, an effect dependent on type I interferon induction in the irradiated tumor4-6. The latter is essential for...
Paper Details
Title
Radiotherapy induces responses of lung cancer to CTLA-4 blockade
Published Date
Nov 5, 2018
Volume
24
Issue
12
Pages
1845 - 1851
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