Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors

Volume: 160, Pages: 17 - 24
Published: Dec 1, 2018
Abstract
Zika virus NS2B-NS3 protease plays an essential role in viral replication by processing the viral polyprotein into individual proteins. The viral protease is therefore considered as an ideal antiviral drug target. To facilitate the development of protease inhibitors, we report three high-resolution co-crystal structures of bZiPro with peptidomimetic inhibitors composed of a P1-P4 segment and different P1′ residues. Compounds 1 and 2 possess...
Paper Details
Title
Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors
Published Date
Dec 1, 2018
Volume
160
Pages
17 - 24
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