Intensive care medicine

Vitamin C

Vitamin

Critically ill

Biology

Clinical trial

Endocrinology

Food science

Immunology

Bioinformatics

Immune system

Internal medicine

Pharmacology

Medicine

Ascorbic acid

World Journal of Critical Care Medicine

Ascorbic acid (vitamin C) elicits pleiotropic effects in the body.Among its functions, it serves as a potent antioxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology.Furthermore, an increasing body of evidence suggests that highdose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients.This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential.

Vitamin C in the critically ill - indications and controversies