Gene

Oophorectomy

Biology

Endocrinology

Estrogen

Somatic cell

Biochemistry

Physiology

Hysterectomy

Menopause

Internal medicine

Hormone

Medicine

Ovary

Pathology

Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging