Propionibacterium acnes

Caspase 1

Immunology

Dermatology

Medicine

Biochemistry

Pharmacology

Acne

Inflammasome

Chemistry

AIM2

Inflammation

Reactive oxygen species

Phytotherapy Research

Activation of the NACHT, LRR and PYD domains‐containing protein 3 (NLRP3) inflammasome by Propionibacterium acnes ( P . acnes ) is critical for inducing inflammation and aggravating the development of acne lesions. We searched for available small‐molecule inhibitors of the NLRP3 inflammasome that could be topically administered for the treatment of acne. We found that licochalcone A, a chalconoid isolated from the root of Glycyrrhiza inflate , was an effective inhibitor for P . acnes ‐induced NLRP3 inflammasome activation. Licochalcone A blocked P . acnes‐ induced production of caspase‐1(p10) and IL‐1β in primary mouse macrophages and human SZ95 sebocytes, indicating the suppression of NLRP3 inflammasome. Licochalcone A suppressed P . acnes‐ induced ASC speck formation and mitochondrial reactive oxygen species. Topical application of licochalcone A to mouse ear skin attenuated P . acnes ‐induced skin inflammation as shown by histological assessment, ear thickness measurement, and inflammatory gene expression....

Licochalcone A attenuates acne symptoms mediated by suppression of NLRP3 inflammasome