Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates
Abstract
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. EOC dissemination is predominantly via direct extension of cells and multicellular aggregates (MCAs) into the peritoneal cavity, which adhere to and induce retraction of peritoneal mesothelium and proliferate in the submesothelial matrix to generate metastatic lesions. Metastasis is facilitated by the accumulation of malignant ascites (500 ml to >2 l), resulting...
Paper Details
Title
Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates
Published Date
Sep 1, 2018
Journal
Volume
11
Issue
9
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