Receptor

Model organism

Drosophila melanogaster

Bioinformatics

Biology

Gene

Psychiatry

Glycation

Psychological intervention

Longevity

Caenorhabditis elegans

Proteostasis

Genetics

Medicine

Cell Metabolism

Chaudhuri et al. discuss mechanistic evidence for the role of glycolytic byproducts that lead to accumulation of advanced glycation end products (AGEs) in the onset of age-related diseases. They outline how model organisms can unveil these mechanisms that will help develop better therapeutics to overcome diabetic pathologies and neurodegenerative diseases.

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality