Abstract 15361: Loss of Caveolin-3 Disrupts Mouse Sinoatrial Node Pacemaking and Stimulates Atrial Arrhythmogenesis
Abstract
Introduction: Caveolae represent a population of caveolin-3 (Cav3)-containing membrane microdomains housing a number of ion channels and transporters that are involved in sinoatrial node (SAN) pacemaking. Cav3 organizes these channels within macromolecular signaling complexes providing highly localized autonomic regulation of the SAN. Hypothesis: Cav3 is required for functional integrity of the SAN, synchronizing Ca release and Ca-voltage...
Paper Details
Title
Abstract 15361: Loss of Caveolin-3 Disrupts Mouse Sinoatrial Node Pacemaking and Stimulates Atrial Arrhythmogenesis
Published Date
Nov 11, 2016
Journal
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