Aliphatic C–H Oxidations for Late-Stage Functionalization

The atomistic change of C(sp3)–H to C(sp3)–O can have a profound impact on the physical and biological properties of small molecules. Traditionally, chemical synthesis has relied on pre-existing functionality to install new functionality, and directed approaches to C–H oxidation are an extension of this logic. The impact of developing undirected C–H oxidation reactions with controlled site-selectivity is that scientists gain the ability to...