Preclinical efficacy studies of DS-1062a, a novel TROP2-targeting antibody-drug conjugate with a novel DNA topoisomerase I inhibitor DXd.

Published on Jun 1, 2018in Journal of Clinical Oncology32.956
· DOI :10.1200/JCO.2018.36.15_SUPPL.E24206
Daisuke Okajima4
Estimated H-index: 4
(Daiichi Sankyo),
Satoru Yasuda3
Estimated H-index: 3
(Daiichi Sankyo)
+ 13 AuthorsToshinori Agatsuma12
Estimated H-index: 12
(Daiichi Sankyo)
Source
Abstract
e24206Background: DS-1062a is a trophoblast cell surface protein 2 (TROP2)-targeting antibody-drug conjugate (ADC) comprised of a humanized anti-TROP2 monoclonal antibody, enzymatically cleavable p...
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Abstract TROP2 is a type I transmembrane glycoprotein originally identified in human trophoblast cells that is overexpressed in several types of cancer. To better understand the role of TROP2 in cancer, we herein aimed to develop a sensitive and specific anti-TROP2 monoclonal antibody (mAb) for use in flow cytometry, Western blot, and immunohistochemistry using a Cell-Based Immunization and Screening (CBIS) method. Two mice were immunized with N-terminal PA-tagged and C-terminal RAP/MAP-tagged T...
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