Original paper
Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
Abstract
Reperfusion as a therapeutic intervention for acute myocardial infarction-induced cardiac injury itself induces further cardiomyocyte death. β-arrestin (βarr)-biased β-adrenergic receptor (βAR) activation promotes survival signaling responses in vitro; thus, we hypothesize that this pathway can mitigate cardiomyocyte death at the time of reperfusion to better preserve function. However, a lack of efficacious βarr-biased orthosteric small...
Paper Details
Title
Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
Published Date
Jan 1, 2018
Journal
Volume
8
Issue
17
Pages
4664 - 4678
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Notes
History