Intramolecular force

Supramolecular chemistry

Crystal engineering

Materials science

Halogen bond

Crystal structure

Non-covalent interactions

Molecule

Intermolecular force

Nanotechnology

Organic chemistry

Crystallography

Chemistry

Chalcogen

Hydrogen bond

Angewandte Chemie International Edition

In the last few decades, "unusual" noncovalent interactions like anion-π and halogen bonding have emerged as interesting alternatives to the ubiquitous hydrogen bonding in many research areas. This is also true, to a somewhat lesser extent, for chalcogen bonding, the noncovalent interaction involving Lewis acidic chalcogen centers. Herein, we aim to provide an overview on the use of chalcogen bonding in crystal engineering and in solution, with a focus on the recent developments concerning intermolecular chalcogen bonding in solution-phase applications. In the solid phase, chalcogen bonding has been used for the construction of nano-sized structures and the self-assembly of sophisticated self-complementary arrays. In solution, until very recently applications mostly focused on intramolecular interactions which stabilized the conformation of intermediates or reagents. In the last few years, intermolecular chalcogen bonding has increasingly also been exploited in solution, most notably in anion recognition and transport as well as in organic synthesis and organocatalysis.

Chalcogen Bonding: An Overview