Impact of Renal Function on Outcomes With Edoxaban in Real-World Patients With Atrial Fibrillation

Background and Purpose— Edoxaban is a direct oral factor Xa inhibitor with proven efficacy and safety among patients with atrial fibrillation. Concerns have been raised about an excess of stroke among patients with creatinine clearance (CrCl) >95 mg/mL treated with edoxaban. We assessed the real-world effectiveness and safety of edoxaban in atrial fibrillation patients in relation to CrCl. Methods— In the Korean National Health Insurance...