Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Published on Nov 1, 2018in CA: A Cancer Journal for Clinicians292.278
· DOI :10.3322/CAAC.21492
Freddie Bray119
Estimated H-index: 119
(IARC: International Agency for Research on Cancer),
Jacques Ferlay77
Estimated H-index: 77
(IARC: International Agency for Research on Cancer)
+ 3 AuthorsAhmedin Jemal139
Estimated H-index: 139
(ACS: American Cancer Society)
Sources
Abstract
This article provides a status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions. There will be an estimated 18.1 million new cancer cases (17.0 million excluding nonmelanoma skin cancer) and 9.6 million cancer deaths (9.5 million excluding nonmelanoma skin cancer) in 2018. In both sexes combined, lung cancer is the most commonly diagnosed cancer (11.6% of the total cases) and the leading cause of cancer death (18.4% of the total cancer deaths), closely followed by female breast cancer (11.6%), prostate cancer (7.1%), and colorectal cancer (6.1%) for incidence and colorectal cancer (9.2%), stomach cancer (8.2%), and liver cancer (8.2%) for mortality. Lung cancer is the most frequent cancer and the leading cause of cancer death among males, followed by prostate and colorectal cancer (for incidence) and liver and stomach cancer (for mortality). Among females, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death, followed by colorectal and lung cancer (for incidence), and vice versa (for mortality); cervical cancer ranks fourth for both incidence and mortality. The most frequently diagnosed cancer and the leading cause of cancer death, however, substantially vary across countries and within each country depending on the degree of economic development and associated social and life style factors. It is noteworthy that high-quality cancer registry data, the basis for planning and implementing evidence-based cancer control programs, are not available in most low- and middle-income countries. The Global Initiative for Cancer Registry Development is an international partnership that supports better estimation, as well as the collection and use of local data, to prioritize and evaluate national cancer control efforts. CA: A Cancer Journal for Clinicians 2018;0:1-31. © 2018 American Cancer Society.
Figures & Tables
Download
📖 Papers frequently viewed together
48.6k Citations
108k Citations
7,252 Citations
References62
Newest
#1Rafael AlonsoH-Index: 6
#2Marion Piñeros (IARC: International Agency for Research on Cancer)H-Index: 26
Last. Freddie Bray (IARC: International Agency for Research on Cancer)H-Index: 119
view all 7 authors...
Abstract Background Uruguay, a country with one of the highest lung cancer rates worldwide, initiated a series of comprehensive anti-smoking measures in 2005. We assess the tobacco control policies in the context of cohort-driven lung cancer incidence trends over a 25-year period, providing baseline predictions to 2035. Methods Using data from the National Cancer Registry of Uruguay, an age-period-cohort analysis of trends 1990–2014 was performed. The NORDPRED package was used to predict the ann...
10 CitationsSource
Abstract Background Previous studies showed a higher incidence of lung cancer among young women than among young men in the United States. Whether this pattern has continued in contemporary birth c...
124 CitationsSource
#1David C. Grossman (KP: Kaiser Permanente)H-Index: 19
#2Susan J. Curry (UI: University of Iowa)H-Index: 89
Last. Chien-Wen Tseng (UH: University of Hawaii)H-Index: 45
view all 18 authors...
Importance In the United States, the lifetime risk of being diagnosed with prostate cancer is approximately 11%, and the lifetime risk of dying of prostate cancer is 2.5%. The median age of death from prostate cancer is 80 years. Many men with prostate cancer never experience symptoms and, without screening, would never know they have the disease. African American men and men with a family history of prostate cancer have an increased risk of prostate cancer compared with other men. Objective To ...
452 CitationsSource
#1Katrina F BrownH-Index: 1
#2Harriet RumgayH-Index: 1
Last. D. Max Parkin (QMUL: Queen Mary University of London)H-Index: 16
view all 15 authors...
Changing population-level exposure to modifiable risk factors is a key driver of changing cancer incidence. Understanding these changes is therefore vital when prioritising risk-reduction policies, in order to have the biggest impact on reducing cancer incidence. UK figures on the number of risk factor-attributable cancers are updated here to reflect changing behaviour as assessed in representative national surveys, and new epidemiological evidence. Figures are also presented by UK constituent c...
179 CitationsSource
#1Louise F. Wilson (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 16
#2Annika Antonsson (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 25
Last. David C. Whiteman (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 85
view all 10 authors...
Cancer is a leading cause of disease burden in Australia, particularly fatal burden, accounting for an estimated thirty percent of deaths. Many cancers develop because of exposure to lifestyle and environmental factors that are potentially modifiable. We aimed to quantify the proportions and numbers of cancer deaths and cases in Australia in 2013 attributable to 20 modifiable factors in eight broad groupings that are established causes of cancer, namely: tobacco smoke (smoking and second-hand), ...
41 CitationsSource
#1Farhad IslamiH-Index: 74
#2Ann Goding SauerH-Index: 22
Last. Susan M. GapsturH-Index: 103
view all 14 authors...
Contemporary information on the fraction of cancers that potentially could be prevented is useful for priority setting in cancer prevention and control. Herein, the authors estimate the proportion and number of invasive cancer cases and deaths, overall (excluding nonmelanoma skin cancers) and for 26 cancer types, in adults aged 30 years and older in the United States in 2014, that were attributable to major, potentially modifiable exposures (cigarette smoking; secondhand smoke; excess body weigh...
425 CitationsSource
#1R. KvåleH-Index: 1
#2Tor Åge MyklebustH-Index: 15
Last. Bjørn MøllerH-Index: 12
view all 6 authors...
In recent decades, management of prostate and breast cancer patients has changed considerably. The purpose of our study is to interpret patterns of prostate and breast cancer incidence and mortality in four Nordic countries across age groups and time periods. Prostate and breast cancer incidence and mortality data (1975–2013) were obtained from the NORDCAN database. Joinpoint regression models were used to identify changes in the trends. A more prominent increase in prostate than breast cancer i...
12 CitationsSource
#1Salvatore Vaccarella (IARC: International Agency for Research on Cancer)H-Index: 43
#2Mathieu Laversanne (IARC: International Agency for Research on Cancer)H-Index: 19
Last. Freddie Bray (IARC: International Agency for Research on Cancer)H-Index: 119
view all 4 authors...
The vast majority (86% or 453,000 cases) of the global burden of cervical cancer occurs in Africa, Latin America and the Caribbean, and Asia, where one in nine new cancer cases are of the cervix. Although the disease has become rare in high-resource settings (e.g. in North America, parts of Europe, Japan) that have historically invested in effective screening programmes, the patterns and trends are variable elsewhere. While favourable incidence trends have been recorded in many populations in As...
55 CitationsSource
#1Melina Arnold (IARC: International Agency for Research on Cancer)H-Index: 24
#2Mathieu Laversanne (IARC: International Agency for Research on Cancer)H-Index: 19
Last. Freddie Bray (IARC: International Agency for Research on Cancer)H-Index: 119
view all 5 authors...
Predicting the Future Burden of Esophageal Cancer by Histological Subtype: International Trends in Incidence up to 2030
150 CitationsSource
#1Melina Arnold (IARC: International Agency for Research on Cancer)H-Index: 24
#2Mónica S. Sierra (IARC: International Agency for Research on Cancer)H-Index: 12
Last. Freddie Bray (IARC: International Agency for Research on Cancer)H-Index: 119
view all 6 authors...
Objective The global burden of colorectal cancer (CRC) is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030. In this study, we aim to describe the recent CRC incidence and mortality patterns and trends linking the findings to the prospects of reducing the burden through cancer prevention and care. Design Estimates of sex-specific CRC incidence and mortality rates in 2012 were extracted from the GLOBOCAN database. Temporal patterns were assessed for 37 ...
1,969 CitationsSource
Cited By34569
Newest
#1Xiaorong Yang (SDU: Shandong University)H-Index: 1
#2Tongchao Zhang (SDU: Shandong University)
Last. Shaowei Sang (SDU: Shandong University)H-Index: 10
view all 5 authors...
Abstract null null Introduction null Understanding the latest global spatio-temporal pattern of lung cancer burden attributable to ambient fine particulate matter pollution (PM2.5) is crucial to prioritize global lung cancer prevention, as well as environment improvement. null null null Methods null Data on lung cancer attributable to ambient PM2.5 were downloaded from the Global Burden of Disease Study (GBD) 2019. The numbers and age-standardized rates on lung cancer mortality (ASMR) and disabi...
Source
#1KumarRahul (IITR: Indian Institute of Technology Roorkee)
#2GuptaAnkur (IITR: Indian Institute of Technology Roorkee)
Last. RamanBalasubramanian (IITR: Indian Institute of Technology Roorkee)
view all 4 authors...
Brain tumors are one of the critical malignant neurological cancers with the highest number of deaths and injuries worldwide. They are categorized into two major classes, high-grade glioma (HGG) an...
Source
#1Mostafa M. Elbadawi (Kafrelsheikh University)H-Index: 1
#2Ahmed I. Khodair (Kafrelsheikh University)H-Index: 18
Last. Khaled R.A. Abdellatif (Beni-Suef University)H-Index: 21
view all 6 authors...
Abstract null null In our endeavors to develop potent anticancer agents, novel two series of 3,5-disubstituted-2-thiohydantoins 5a–c and the S-methyl counterparts 6a–c were designed and synthesized. The structural modifications were based on some reported thiohydantoins derivatives which showed promising antiproliferative activity. The activity of the compounds was verified via the in vitro cytotoxicity assay against prostate (PC-3) and breast (MCF-7) cancer cell lines along with normal lung fib...
Source
#1Jia Liu (HUST: Huazhong University of Science and Technology)H-Index: 24
#2Daan Fu (HUST: Huazhong University of Science and Technology)H-Index: 2
Last. Qiying Lv (HUST: Huazhong University of Science and Technology)H-Index: 14
view all 13 authors...
Abstract null null Distant metastases and chemotherapy repellency are the key causes of colorectal cancer (CRC)-related mortality. Regorafenib, an oral multi-kinase inhibitor approved for treating advanced CRC with distant metastases and/or chemo-resistance, however only improves median overall survival by 1.4 months. Such limited therapeutic effect is likely due to the low bioavailability of orally administered hydrophobic regorafenib. A regorafenib nanodrug is fabricated by one-step self-assem...
Source
#1Yafeng Qi (THU: Tsinghua University)
#2Lin Yang (Peking Union Medical College)H-Index: 10
Last. Jianbin Luo (THU: Tsinghua University)H-Index: 55
view all 8 authors...
Intraoperative detection of the marginal tissues is the last and most important step to complete the resection of adenocarcinoma and squamous cell carcinoma. However, the current intraoperative diagnosis is time-consuming and requires numerous steps including staining. In this paper, we present the use of Raman spectroscopy with deep learning to achieve accurate diagnosis with stain-free process. To make the spectrum more suitable for deep learning, we utilize an unusual way of thinking which re...
Source
Abstract null null The mortality of ovarian cancer is closely related to its poor rate of early detection. In the search of an efficient diagnosis method, Raman spectroscopy of blood features as a promising technique allowing simple, rapid, minimally-invasive and cost-effective detection of cancers, in particular ovarian cancer. Although Raman spectroscopy has been demonstrated to be effective to detect ovarian cancers with respect to normal controls, a binary classification remains idealized wi...
Source
#1Ishrat Mahjabeen (CUI: COMSATS Institute of Information Technology)H-Index: 14
#2Muhammad Rizwan (CUI: COMSATS Institute of Information Technology)H-Index: 67
Last. Mahmood Akhtar Kayani (CUI: COMSATS Institute of Information Technology)H-Index: 19
view all 6 authors...
Abstract null null Aims null The purpose of the present study was to analyze the role of selected polymorphisms of SIRT3 and SIRT5 in gastric carcinogenesis. Methods: For this study, 500 blood samples of GC patients and 500 blood samples of healthy individuals were collected. Six selected polymorphisms of mitochondrial sirtuins were analyzed for analysis by Tetra-Arms PCR followed by DNA sequencing. Results: Mutant allele frequencies of selected polymorphisms [rs3782116 (p
Source
Abstract null null Specific classes of biomolecules may act as putative biomarkers in altered metabolic pathways related to breast cancer diagnosis, classification, and prognosis. This study aim an integrated metabolomic profiling of blood serum and urine from invasive ductal ER+ breast cancer cases (stage 2 and 3) and matched controls, using high performance liquid chromatography coupled with mass spectrometry. More than 400 metabolites were identified in both biofluids, either common (96 molec...
Source
#1Zhang Lihao (CAS: Chinese Academy of Sciences)
#2Chengjian Li (SHU: Shanghai University)
Last. Huang Xia (CAS: Chinese Academy of Sciences)
view all 10 authors...
Abstract null null Breast cancer is a major health threat for women. The drug responses associated with different breast cancer subtypes have obvious effects on therapeutic outcomes; therefore, the accurate classification of breast cancer subtypes is critical. Breast cancer subtype classification has recently been examined using various methods, and Raman spectroscopy has emerged as an effective technique that can be used for noninvasive breast cancer analysis. However, the accurate and rapid cl...
Source
#1Ting Sun (China Jiliang University)H-Index: 2
#2Yannan Hu (China Jiliang University)
Last. Pei Xu (China Jiliang University)H-Index: 13
view all 8 authors...
Abstract null null Widespread heavy metal pollution in soils has posed serious threat to vegetable production and food security, yet little is still known about heavy metal accumulation and distribution in the majority of vegetable crops. Here, we report the generation of a tissue atlas of cadmium accumulation in zucchini (Cucurbita pepo var. Giromontial), a globally important cucurbit crop, based on two-season experiment with six genotypes grown under cadmium contaminated soils. Plant growth an...
Source