HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Osteosarcoma is the most common primary bone tumor in children and adolescents. Unfortunately, osteosarcoma treatments often fail due to the development of chemoresistance, of which the underlying molecular mechanisms still remain unclear. In this study, we demonstrated that HSP90AA1 gene is responsible for drug resistance in osteosarcoma through an autophagy-related mechanism. shRNAs were transfected into osteosarcoma cells for knockdown of...