The development of photoactive and biocompatible nanomaterials is a current major challenge of materials science and nanotechnology, as they will contribute to promoting current and future biomedical applications. A growing strategy in this direction consists of using biologically inspired hybrid materials to maintain or even enhance the optical properties of chromophores and fluorophores in biological media. Within this area, porphyrinoids constitute the most important family of organic photosensitizers. The following extensive review will cover their incorporation into different kinds of photosensitizing biohybrid materials, as a fundamental research effort toward the management of light for biomedical use, including technologies such as photochemical internalization (PCI), photoimmunotherapy (PIT), and theranostic combinations of fluorescence imaging and photodynamic therapy (PDT) or photodynamic inactivation (PDI) of microorganisms.
#1Shukun Li(CAS: Chinese Academy of Sciences)H-Index: 17
#2Ruirui Xing(CAS: Chinese Academy of Sciences)H-Index: 32
Last. Xuehai Yan(CAS: Chinese Academy of Sciences)H-Index: 67
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Abstract In this review we consider assembled nanodrugs as a type of nanoscale drugs formed by molecular self-assembly and associated with precise organization of multiple non-covalent interactions. Their typical feature is that the drug itself is considered as one of the building blocks with flexibly interplaying interaction for supramolecular assembly and nanostructure formation with robust stability and high loading efficiency in a controlled and tunable way. The super stability with retained...
: Although fibrillar amyloid beta peptide (Aβ) aggregates are one of the major hallmarks of Alzheimer's disease, increasing evidence suggests that soluble Aβ oligomers are the primary toxic species. Targeting the oligomeric species could represent an effective strategy to interfere with Aβ toxicity. In this work, the biological properties of 5[4-(6-O-β-cyclodextrin)-phenyl],10,15,20-tri(4-hydroxyphenyl)-porphyrin and its zinc complex were tested, as new molecules that interact with Aβ and effect...
AbstractAcid-base equilibrium of the “one-face”-hindered sulfonated porphyrin, α5,15-[2,2′(dodecamethyleneoxy),(5-sulfonato)diphenyl]-10,20-bis(2-hydroxy,5-sulfonatophenyl)porphyrinato iron(III), has been studied by paramagnetic 1H NMR. The isotropically shifted signals change in a fast exchange regime on the NMR time-scale. 1H longitudinal relaxation times and temperature dependence of the chemical shifts were measured and analyzed. The electronic structure of hydroxo specie is characteristic o...
We herein report the synthesis and analysis of a novel aza-BODIPY–antibody conjugate, formed by controlled and regioselective bioconjugation methodology. Employing the clinically relevant antibody, which targets HER2 positive cancers, represents an excellent example of an antibody targeting strategy for this class of near-IR emitting fluorophore. The NIR fluorescence and binding properties were validated through in vitro studies using live cell confocal imaging.
#1Haifeng Sun(CAS: Chinese Academy of Sciences)H-Index: 3
#2Shukun Li(CAS: Chinese Academy of Sciences)H-Index: 17
Last. Xuehai Yan(CAS: Chinese Academy of Sciences)H-Index: 67
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Abstract Nanomaterials constructed by self-assembly of biomolecules are of particular interest as drug delivery carriers in biomedicine. However, supramolecular construction of nanoparticles by self-assembly of highly hydrophilic biomolecules such as hyaluronic acid still remains a formidable challenge due to their water solubility. Herein, we propose a strategy to fabricate stable nanoparticles by self-assembly of hyaluronic acid without the need of modification by hydrophobic groups. This stra...
#1P. Sarbadhikary(HBNI: Homi Bhabha National Institute)H-Index: 1
#2A. Dube(HBNI: Homi Bhabha National Institute)H-Index: 1
The insertion of suitable metals or high Z elements in tumour-avid tetrapyrrole compounds is a promising approach to obtain potential agents for multimodal cancer therapeutics and tumour imaging. Using chlorin p6, a chlorophyll derivative, we synthesized a novel iodinated chlorin p6-copper complex (ICp6-Cu) that can be applied to the photodynamic therapy and photon activation therapy of cancer. In the present study, we investigated the interaction of ICp6-Cu with human serum albumin (HSA) using ...
Last. Xuehai Yan(CAS: Chinese Academy of Sciences)H-Index: 67
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Biomimetic organization provides a promising strategy to develop functional materials and understand biological processes. However, how to mimic complex biological systems using simple biomolecular units remains a great challenge. Herein, we design and fabricate a biomimetic cyanobacteria model based on self-integration of small bioinspired molecules, including amphiphilic amino acid, 3,4-dihydroxyphenylalanine (DOPA), and metalloporphyrin and cobalt oxide nanoparticles (Co3O4 NPs), with the ass...
This review focuses on progress in the development of different approaches to the design of steroid (e.g. estrogens, androgens, cholesterol) conjugates with coordination assemblies of metalloporphyrins, phthalocyanines and related complexes. Porphyrins and phthalocyanines have received considerable attention due to their novel composition, intriguing spectroscopic, photophysical, and redox properties, and potential application in light-harvesting and optoelectronic devices. With the development ...
#1Markus Sauer(UMCG: University Medical Center Groningen)H-Index: 1
#2Katrin Paeschke(UMCG: University Medical Center Groningen)H-Index: 17
The concept that G-quadruplex (G4) structures can form within DNA or RNA in vitro has been long known and extensively discussed. In recent years, accumulating evidences imply that G-quadruplex structures form in vivo . Initially, inefficient regulation of G-quadruplex structures was mainly associated with genome instability. However, due to the location of G-quadruplex motifs and their evolutionary conservation, different cellular functions of these structures have been postulated (e.g. in telom...
Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention for decades. Recent methodological advances have advanced the identification and characterization of G-quadruplexes in vivo as well as in vitro , and at a much higher resolution and throughput, which has greatly expanded our current understanding of G-quadruplex structure...
Abstract null null The hypoxic tumour microenvironment and poor spatiotemporal localization of photosensitizers are two significant obstacles that limit practical applications of photodynamic therapy. In response, a biocompatible, light-activatable liposome integrated with both a zinc phthalocyanine photodynamic component and Pt nanoparticles-decorated with MnO2 catalase-mimicking component are engineered. This multifunctional system was rationally designed using unsaturated phospholipids to ach...
Antimicrobial photodynamic therapy (APDT) employs a photosensitizer, light, and molecular oxygen to treat infectious diseases via oxidative damage, with a low likelihood for the development of resistance. For optimal APDT efficacy, photosensitizers with cationic charges that can permeate bacteria cells and bind intracellular targets are desired to not limit oxidative damage to the outer bacterial structure. Here we report the application of brominated DAPI (Br-DAPI), a water-soluble, DNA-binding...
A pH-responsive drug delivery system (DDS) based on mesoporous silica nanoparticles (MSNs) has been prepared for the delivery of three anticancer drugs with different modes of action. The novelty of this system is its ability to combine a synergistic chemotherapy and photodynamic therapy. Herein, a photoactive conjugate of a phthalocyanine (Pc) and a topoisomerase I inhibitor (topo-I), namely camptothecin (CPT), linked by a polyethylene glycol (PEG) chain has been synthesized and then loaded int...
Metal oxides have been widely used in wastewater treatment, but due to their limitations there is a need of some modifications to make them an efficient photocatalyst. Many support materials are used to enhance the photocatalytic efficacy of many photocatalysts. Recently, cellulose nanomaterials have been utilized as green prototype for the preparation of metal or metal oxide nanomaterials and to improve their photocatalytic efficacy as it acts as a good adsorbent and support material. Cellulose...
#1Xuejiao Guo(CityU: City University of Hong Kong)
#2Honglin Jin(HUST: Huazhong University of Science and Technology)H-Index: 18
Last. Pui-Chi Lo(CityU: City University of Hong Kong)H-Index: 39
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A zinc(ii) phthalocyanine (ZnPc) was conjugated to doxorubicin (Dox) via an acid-labile hydrazone linker. The resulting ZnPc-Dox conjugate was then encapsulated into polymeric micelles formed through self-assembly of a block copolymer of poly(ethylene glycol) and poly(d,l-lactide) both in the absence and presence of the hypoxia-activated prodrug tirapazamine (TPZ) to give ZnPc-Dox@micelles and ZnPc-Dox/TPZ@micelles respectively. These polymeric micelles exhibited an excellent stability in aqueou...
Stimuli-responsive recombinant elastin-like polypeptides (ELPs) are artificial protein polymers derived from the hydrophobic domain of tropoelastin that have attracted significant interest for drug delivery and tissue engineering applications. In the present study, we have conjugated a photosensitizer (PS) to a hydrophobic methionine-containing ELP scaffold, which upon reaction with singlet oxygen (1O2) is transformed into a hydrophilic sulfoxide derivative facilitating the disassembly of photos...
Last. Shengqian Ma(UNT: University of North Texas)H-Index: 86
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Metallocorrole macrocycles that represent a burgeoning class of attractive metal-complexes from the porphyrinoid family, have attracted great interest in recent years owing to their unique structure and excellent performance revealed in many fields, yet further functionalization through incorporating these motifs into porous nanomaterials employing the bottom-up approach is still scarce and remains synthetically challenging. Here, we report the targeted synthesis of porous organic polymers (POPs...
In the endeavor of extending the clinical use of photodynamic therapy (PDT) for the treatment of superficial cancers and other neoplastic diseases, deeper knowledge and control on the subcellular processes that determine the response of photosensitizers (PS) are needed. Recent strategies in this direction involve the use of activatable and nanostructured PS. Herein both capacities have been tuned in two dendritic zinc (II) phthalocyanine (ZnPc) derivatives, either asymmetrically or symmetrically...
Abstract Deprotonation of free-base [30]trithia-2,3,5,10,12,13,15,20,22,23,25,30-dodecaazahexaphyrin (hemihexaphyrazine, H3Hhp) and 5, 10, 15- triphenylcorrole (H3TPCor) macrocycles by an excess of lithium diethylamide, LiNEt2, in the presence of three equivalents of cryptand[2.2.2] has been studied. Crystallization of the obtained products after the reaction allows the isolation of crystalline {Cryptand[2.2.2](Li)}2{Li3Cl(Hhp)}2⋅6C6H4Cl2 (1) and {Cryptand[2.2.2](Li)} {H2TPCor)⋅0.5C6H4Cl2 (2) sa...
