Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease
Abstract
Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat, largely because the blood-brain barrier blocks passage of most drugs. Here we find exosomes from blood showing natural brain targeting ability which involved the transferrin-transferrin receptor interaction. Thus, we develop a biocompatible platform based on blood exosomes for delivering drugs across the blood-brain barrier. Blood...
Paper Details
Title
Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease
Published Date
Oct 10, 2018
Volume
287
Pages
156 - 166
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