Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Volume: 50, Issue: 9, Pages: 1219 - 1224
Published: Aug 13, 2018
Abstract
A key public health need is to identify individuals at high risk for a given disease to enable enhanced screening or preventive therapies. Because most common diseases have a genetic component, one important approach is to stratify individuals based on inherited DNA variation1. Proposed clinical applications have largely focused on finding carriers of rare monogenic mutations at several-fold increased risk. Although most disease risk is...
Paper Details
Title
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
Published Date
Aug 13, 2018
Volume
50
Issue
9
Pages
1219 - 1224
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