Catalysis

Nucleophilic addition

Lewis acids and bases

Nucleophilic aromatic substitution

Medicinal chemistry

Combinatorial chemistry

Organic chemistry

Mathematics

Nucleophile

Mathematical analysis

Computational chemistry

Quinazolinone

Chemistry

Nucleophilic substitution

Base (topology)

The Journal of Organic Chemistry

This paper describes a convenient method to synthesize quinazolin-4(3 H)-ones from simple and readily available 2-halobenzamides and nitriles. The Lewis acid Cu-catalyzed nucleophilic addition of 2-halobenzamide to nitriles followed by SNAr reaction proceeds smoothly in the presence of tBuOK as a base to produce quinazolinone derivatives.

Synthesis of Quinazolin-4(3<i>H</i>)-ones via the Reaction of 2-Halobenzamides with Nitriles

Synthesis of Quinazolin-4(3H)-ones via the Reaction of 2-Halobenzamides with Nitriles