Degradation and Remodeling of Epitaxially Grown Collagen Fibrils.

Published on Feb 1, 2019in Cellular and Molecular Bioengineering1.72
· DOI :10.1007/S12195-018-0547-6
Juan Wang5
Estimated H-index: 5
(Iowa State University),
Anuraag Boddupalli4
Estimated H-index: 4
(Iowa State University)
+ 4 AuthorsIan C. Schneider14
Estimated H-index: 14
(Iowa State University)
Sources
Abstract
Introduction The extracellular matrix (ECM) in the tumor microenvironment contains high densities of collagen that are highly aligned, resulting in directional migration called contact guidance that facilitates efficient migration out of the tumor. Cancer cells can remodel the ECM through traction force controlled by myosin contractility or proteolytic activity controlled by matrix metalloproteinase (MMP) activity, leading to either enhanced or diminished contact guidance.
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