Antibody-dependent enhancement

Virus

Monoclonal antibody

Biology

Neutralization

Viral replication

Antibody

Virology

Immunology

Ebola virus

Ebolavirus

Neutralizing antibody

Immune system

Cell Host & Microbe

While antibodies provide protection against Ebola virus, the mechanism is unclear. Gunn et al. dissect the contribution of Fc-functions to protection using a library of Ebola virus-specific antibodies. Fc function was a critical predictor of protection across neutralizing and non-neutralizing antibodies, pointing to synergy between Fc- and Fab-mediated antibody-functions against Ebola.

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus