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Original paper

Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis

Volume: 15, Issue: 1, Pages: 71 - 79
Published: Nov 30, 2018
Abstract
Terpene synthases typically form complex molecular scaffolds by concerted activation and cyclization of linear starting materials in a single enzyme active site. Here we show that iridoid synthase, an atypical reductive terpene synthase, catalyzes the activation of its substrate 8-oxogeranial into a reactive enol intermediate, but does not catalyze the subsequent cyclization into nepetalactol. This discovery led us to identify a class of...
Paper Details
Title
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis
Published Date
Nov 30, 2018
Volume
15
Issue
1
Pages
71 - 79
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