Original paper
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis
Abstract
Terpene synthases typically form complex molecular scaffolds by concerted activation and cyclization of linear starting materials in a single enzyme active site. Here we show that iridoid synthase, an atypical reductive terpene synthase, catalyzes the activation of its substrate 8-oxogeranial into a reactive enol intermediate, but does not catalyze the subsequent cyclization into nepetalactol. This discovery led us to identify a class of...
Paper Details
Title
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis
Published Date
Nov 30, 2018
Journal
Volume
15
Issue
1
Pages
71 - 79