Pathology

Nanotechnology

Electrode

Inflammatory bowel disease

Disease

Reactive oxygen species

Proinflammatory cytokine

Physical chemistry

Nanomedicine

Nanoparticle

Chemistry

Materials science

Immunology

Colitis

Inflammation

Prussian blue

Biosafety

Cancer research

Electrochemistry

Biochemistry

Medicine

Pharmacology

ACS Applied Materials & Interfaces

The overproduction of reactive oxygen species (ROS) is central to the progression of inflammatory bowel disease (IBD), which may be the potential therapeutic target. Prussian blue (PB) nanoparticles with good biosafety can act as an artificial nanozyme, effectively scavenging ROS. To date, PB-based nanomaterials have not been developed and utilized for treatment of IBD. In this study, poly(vinylpyrrolidone)-modified Prussian blue (PPB) nanoparticles are constructed with good physiological stability and biosafety by a simple and efficient method. The prepared PPBs with capabilities of scavenging ROS and inhibiting proinflammatory cytokine significantly reduce colitis in mice without distinct side effects via intravenous administration. This report provides a demonstration of the protective effect of PB-based nanomedicine against IBD in living animals, offering hope and a potential alternative treatment option for patients suffering from IBD.

Prussian Blue Nanozyme with Multienzyme Activity Reduces Colitis in Mice