Preparation of Icariin and Deferoxamine Functionalized Poly(l-lactide)/chitosan Micro/Nanofibrous Membranes with Synergistic Enhanced Osteogenesis and Angiogenesis
Published on Jul 16, 2018
· DOI :10.1021/ACSABM.8B00129
Osteogenesis is tightly complemented with angiogenesis during the bone regeneration process. In this study, to synergistically enhance the osteogenesis and angiogenesis of poly(l-lactide) (PLLA), PLLA/chitosan (PLLA/CS) composite fibrous membrane was prepared first by combining electrospinning and thermally induced phase separation technologies. Then, with the aid of polydopamine (PDA) coating, two types of bioactive molecules of icariin (ICA) and deferoxamine (DFO) were chosen to singly or simultaneously surface modify the as-prepared PLLA/CS-PDA membrane, thereby fabricating PLLA/CS-PDA/ICA, PLLA/CS-PDA/DFO, and PLLA/CS-PDA/ICA/DFO membranes. The morphology and properties of the pristine and modified PLLA fibrous membranes were studied, which revealed that the modified PLLA membrane’s own hierarchical fibrous structure improved hydrophilicity and had better tensile properties by introducing PDA and ICA or DFO. On account of the synergetic contributions of ICA and DFO as well as the hierarchical fibrous ...