Targeting the NLRP3 inflammasome in inflammatory diseases
Abstract
Danger signals are a hallmark of many common inflammatory diseases, and these stimuli can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR- and pyrin domain-containing 3). Once activated, NLRP3 nucleates the assembly of an inflammasome, leading to caspase 1-mediated proteolytic activation of the interleukin-1β (IL-1β) family of cytokines, and induces an inflammatory, pyroptotic cell death. Pharmacological...
Paper Details
Title
Targeting the NLRP3 inflammasome in inflammatory diseases
Published Date
Jul 20, 2018
Volume
17
Issue
8
Pages
588 - 606
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