Highly efficient fluorescent QDs sensor for specific detection of protein through double recognition of hybrid aptamer-molecular imprinted polymers

This work demonstrates a strategy of double recognition hybrid aptamer–molecular imprinted polymer/quantum dots (apt–MIP/QDs) fluorescent sensor for specific recognition of target protein. We selected vinyl modified Mn–doped ZnS QDs as signal source and support. Instead of relying on single source of weak interaction between protein and small molecule monomer, thiol terminated aptamers were used as specific functional monomers to obtain apt–MIP...