Nuclear physics

Radiochemistry

Physics

Positron

Pet imaging

Positron emission

Medicine

Chemistry

Electron

Nuclear medicine

Positron emission tomography

Angewandte Chemie International Edition

Positron emission tomography (PET) is a molecular imaging technology that provides quantitative information about function and metabolism in biological processes in vivo for disease diagnosis and therapy assessment. The broad application and rapid advances of PET has led to an increased demand for new radiochemical methods to synthesize highly specific molecules bearing positron-emitting radionuclides. This Review provides an overview of commonly used labeling reactions through examples of clinically relevant PET tracers and highlights the most recent developments and breakthroughs over the past decade, with a focus on 11 C, 18 F, 13 N, and 15 O.

Chemistry for Positron Emission Tomography: Recent Advances in 11 C‐, 18 F‐, 13 N‐, and 15 O‐Labeling Reactions