The integration of LC‐MS and NMR for the analysis of low molecular weight trace analytes in complex matrices

This review discusses the integration of liquid chromatography (LC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) in the comprehensive analysis of small molecules from complex matrices. We first discuss the steps taken toward making the three technologies compatible, so as to create an efficient analytical platform. The development of online LC‐MS‐NMR, highlighted by successful applications in the profiling of highly concentrated...