Mitochondrial double-stranded RNA triggers antiviral signalling in humans
Abstract
Mitochondria are descendants of endosymbiotic bacteria and retain essential prokaryotic features such as a compact circular genome. Consequently, in mammals, mitochondrial DNA is subjected to bidirectional transcription that generates overlapping transcripts, which are capable of forming long double-stranded RNA structures1,2. However, to our knowledge, mitochondrial double-stranded RNA has not been previously characterized in vivo. Here we...
Paper Details
Title
Mitochondrial double-stranded RNA triggers antiviral signalling in humans
Published Date
Jul 25, 2018
Journal
Volume
560
Issue
7717
Pages
238 - 242
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