Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease
Abstract
Though emerging evidence indicates that the pathogenesis of Parkinson's disease is strongly correlated to the accumulation1,2 and transmission3,4 of α-synuclein (α-syn) aggregates in the midbrain, no anti-aggregation agents have been successful at treating the disease in the clinic. Here, we show that graphene quantum dots (GQDs) inhibit fibrillization of α-syn and interact directly with mature fibrils, triggering their disaggregation. Moreover,...
Paper Details
Title
Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease
Published Date
Jul 9, 2018
Journal
Volume
13
Issue
9
Pages
812 - 818
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