Metabotropic glutamate receptor

Metabotropic glutamate receptor 6

Class C GPCR

Neuroscience

Biology

Excitatory postsynaptic potential

Ionotropic effect

Metabotropic glutamate receptor 7

Receptor

Inhibitory postsynaptic potential

Biochemistry

Metabotropic glutamate receptor 8

Kainate receptor

Long-term depression

Glutamate receptor

Metabotropic receptor

Metabotropic glutamate receptor 2

AMPA receptor

Glutamatergic

Metabotropic glutamate receptor 1

Metabotropic glutamate receptor 5

Neuron

Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as a key neuromodulator to control synapse and circuit function over a wide range of spatial and temporal scales. This functional diversity is decoded by two receptor families: ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The challenges posed by the complexity and physiological importance of each of these subtypes has limited our appreciation and understanding of how these receptors work in concert. In this review, by comparing both receptor families with a focus on their crosstalk, we argue for a more holistic understanding of neural glutamate signaling.

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert