The presence of emerging pollutants in the aquatic environment in relatively small concentrations and the fact that they cannot be removed by conventional water/wastewater treatment processes bring new challenges in terms of adequate selection of technologies from the technical, economical and environmental points of view. Generally, literature discusses emerging pollutants’ removal at significant concentrations (such as those in wastewater), while few studies consider their low concentrations occurring in raw water. This study presents a comprehensive review of the research efforts related to the occurrence, fate, health effects and impacts of emerging pollutants on advanced drinking water treatment and the environmental performance evaluation of different technological options, with a focus on pilot and full-scale installations. All presented case studies consider pollutants removed, process conditions and removal efficiencies, thus making possible comparisons between membrane processes, advanced oxidation processes and adsorption on activated carbon and other materials. The study is completed by an analysis of the environmental assessment instruments (life cycle assessment, carbon, water footprints, other type of assessments) that may be used for selecting sustainable advanced drinking water treatment processes able to remove emerging pollutants. This paper critically reviews the main research topics concerning emerging pollutants: classification, legislative framework, up-to-date removal processes and their environmental performances assessment, to offer a comprehensive analysis of the strategic issues that may constitute future research directions for sustainable water supply .