Objective:Large-vessel vasculitis (LVV) is a serious illness with potentially life-threatening consequences. (18Fluorine) fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) has emerged as a valuable diagnostic tool in suspected LVV, combining the strengths of functional and structural imaging. This study aimed to compare the accuracy of FDG PET-CT and contrast-enhanced CT (CECT) in the evaluation of patients with LVV.Methods:A retrospective database review for LVV patients undergoing CECT and PET-CT between 2011 to 2016 yielded demographics, scan interval and vasculitis type. Qualitative and quantitative PET-CT analyses included aorta:liver FDG uptake, bespoke FDG uptake distribution scores and vascular maximum standardised uptake values (SUVmax). Quantitative CECT data were assessed for wall thickness and mural-lumen ratio. Receiver operating characteristics (ROC) curves were constructed to evaluate comparative diagnostic accuracy and a correlational analysis was conduct...
Large vessel vasculitis (LVV) is defined as a disease mainly affecting the large arteries, with two major variants, Takayasu arteritis (TA) and giant cell arteritis (GCA). GCA often coexists with polymyalgia rheumatica (PMR) in the same patient, since both belong to the same disease spectrum. FDG-PET/CT is a functional imaging technique which is an established tool in oncology, and has also demonstrated a role in the field of inflammatory diseases. Functional FDG-PET combined with anatomical CT ...
#1Hubert de Boysson(UNICAEN: University of Caen Lower Normandy)H-Index: 16
#2A. Dumont(UNICAEN: University of Caen Lower Normandy)H-Index: 7
Last. Achille Aouba(UNICAEN: University of Caen Lower Normandy)H-Index: 27
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Purpose The purpose of our study was to assess the concordance of aortic CT angiography (CTA) and FDG-PET/CT in the detection of large-vessel involvement at diagnosis in patients with giant-cell arteritis (GCA).
Integrated positron emission tomography/computed tomography (PET/CT) with the glucose analogue, 2-[ 18 F]-fluoro-2-deoxy- d -glucose (FDG), is an evolving hybrid imaging technique in the evaluation of an important and diverse group of pathological conditions, which are characterised by infection and aseptic inflammation. With a rapidly expanding body of evidence, it is being increasingly recognised that, in addition to its established role in oncological imaging, FDG PET/CT also has clinical uti...
Large vessel vasculitis (LVV) is an often-reported cause of inflammation of unknown origin (IUO) in elderly people. The objective of this study was to describe the usefulness of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and contrast-enhanced CT in early diagnosis and treatment follow-up of patients with LVV presenting as elderly onset IUO. We retrospectively compared contrast-enhanced CT findings and FDG-PET/CT findings of the patients diagnosed...
1Department of Nuclear Medicine, Universite Catholique de Louvain, Brussels, Belgium; 2Department of Nuclear Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom; 3Nuclear Medicine, Istituto Clinico Humanitas, Milan, Italy; 4Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; 5Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; 6Department of Nuclear Medicine, Beth Israel Deaconess Medical Center, Boston, Mas...
Objective: To investigate the diagnostic performance of 18F-fludeoxyglucose (18F-FDG) positron emission tomography (PET)/CT in patients with suspected large-vessel vasculitis and its potential to evaluate the extent and activity of disease. Methods: 78 consecutive patients (mean age 63 years; 53 females) with suspected large-vessel vasculitis were evaluated with 18F-FDG PET/CT. 18F-FDG uptake in the aorta and major branches was visually graded using a four-point scale and quantified with standar...
#1Qi Cao(UMB: University of Maryland, Baltimore)H-Index: 24
#2Wengan Chen(UMB: University of Maryland, Baltimore)H-Index: 1
: Diagnosis of vasculitis is challenging given the nonspecific manifestations of the diseases. [(18)F]Fluorodeoxyglucose (FDG) positron emission tomography (PET) has been increasingly used for vasculitis in clinic and has been shown to have a potential role in diagnosing large-vessel vasculitis such as giant cell vasculitis and Takayasu vasculitis, in monitoring treatment response, and in predicting disease progression. However, the exact clinical role of FDG PET for vasculitis has not been dete...
Purpose We aimed to assess the impact of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) on the management of patients with suspected large vessel vasculitis.
Last. Alessandro Giordano(UCSC: Catholic University of the Sacred Heart)H-Index: 43
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The objective of this study is to systematically review the role of positron emission tomography (PET) and PET/computed tomography (PET/CT) with fluorine-18-fluorodeoxyglucose (FDG) in patients with large-vessel vasculitis (LVV). A comprehensive literature search of published studies through April 2011 in PubMed/MEDLINE and Scopus databases regarding whole-body FDG-PET and PET/CT in patients with LVV was performed. We identified 32 studies including 604 LVV patients. The main findings of these s...
Purpose The aim of this study was to conduct a systematic review and perform a meta-analysis on the diagnostic performances of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) for giant cell arteritis (GCA), with or without polymyalgia rheumatica (PMR).
With this document, we provide a standard for PET/(diagnostic) CT imaging procedures in cardiovascular diseases that are inflammatory, infective, infiltrative, or associated with dysfunctional innervation (4Is). This standard should be applied in clinical practice and integrated in clinical (multicenter) trials for optimal procedural standardization. A major focus is put on procedures using [18F]FDG, but 4Is PET radiopharmaceuticals beyond [18F]FDG are also described in this document. Whilst the...
With this summarized document we share the standard for positron emission tomography (PET)/(diagnostic)computed tomography (CT) imaging procedures in cardiovascular diseases that are inflammatory, infective, infiltrative, or associated with dysfunctional innervation (4Is) as recently published in the European Journal of Nuclear Medicine and Molecular Imaging. This standard should be applied in clinical practice and integrated in clinical (multicentre) trials for optimal standardization of the pr...
Resume Si l'atteinte des gros troncs arteriels au cours de l'arterite a cellules geantes est. connue de longue date, son importance, en termes de frequence et de possible incidence pronostique, n'est. mise en exergue que depuis deux decades. Outre un risque eleve d'anevrisme aortique retarde, l'atteinte des gros troncs arteriels pourrait conferer une plus grande resistance aux traitements et grever le pronostic cardio-vasculaire lointain. Ces notions sont apparues grâce a des travaux permis par ...
Resumen Objetivo Comparar la PET/TC con 18F-FDG y la angioTC en el diagnostico de la afectacion extracraneal en pacientes con sospecha de vasculitis de grandes vasos (VGV). Material y metodo Estudio retrospectivo en 59 pacientes con sospecha clinica de VGV, estudiados con PET/TC con 18F-FDG y angioTC. En 55 pacientes la PET/TC y angioTC se realizaron simultaneamente en la misma maquina y en 4 pacientes en un intervalo Resultados La PET/TC con 18F-FDG y la angioTC mostraron una elevada especifici...
Abstract Objective Compare 18 F-FDG PET/CT and CTangio in the diagnosis of extracraneal large vessel involvement in patients with suspicion of large vessel vasculitis (LVV). Material and methods A retrospective database reviewed 59 patients with clinical suspicion of LVV undergoing 18 F-FDG PET/CT and CTangio. In 55 patients PET/TC and CTangio were done simultaneously in the same machine and in 4 patients with a scan interval of 1 18 F-FDG vessel/SUVmax liver). CTangio was assessed for concentri...