Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers

Plasma membranes in the human brain can interact with amyloid β-peptide (1–42; Aβ42) and induce Aβ42 fibrillation, which is considered to be a crucial process underlying the neurotoxicity of Aβ42 and the pathogenesis of Alzheimer’s disease (AD). However, the mechanism of membrane-mediated Aβ42 fibrillation at the molecular level remains elusive. Here we study the role of adsorbed Aβ42 peptides on membrane-mediated fibrillation using supported...