Mouse Cre Models for the Study of Bone Diseases

Transgenic Cre lines are a valuable tool for conditionally inactivating or activating genes to understand their function. Here, we provide an overview of Cre transgenic models used for studying gene function in bone cells and discuss their advantages and limitations, with particular emphasis on Cre lines used for studying osteocyte and osteoclast function.Recent studies have shown that many bone cell-targeted Cre models are not as specific as...