Original paper

Adnectin–drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors

Volume: 31, Issue: 5, Pages: 159 - 171
Published: May 1, 2018
Abstract
Tumor-specific delivery of cytotoxic agents remains a challenge in cancer therapy. Antibody-drug conjugates (ADC) deliver their payloads to tumor cells that overexpress specific tumor-associated antigens-but the multi-day half-life of ADC leads to high exposure even of normal, antigen-free, tissues and thus contributes to dose-limiting toxicity. Here, we present Adnectin-drug conjugates, an alternative platform for tumor-specific delivery of...
Paper Details
Title
Adnectin–drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors
Published Date
May 1, 2018
Volume
31
Issue
5
Pages
159 - 171
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