Original paper
Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation
Abstract
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the enhanced response obtained by combinatorial treatments. Methods: We combined RNA-sequencing, flow cytometry and TCR-sequencing to dissect the impact of immunotherapy and of immunotherapy combined with...
Paper Details
Title
Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation
Published Date
Jan 1, 2018
Journal
Volume
8
Issue
13
Pages
3611 - 3628
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Notes
History