Vancomycin

Streptococcus pneumoniae

Antibiotics

Bacteria

Biology

Microbiology

Gene

Methicillin-resistant Staphylococcus aureus

Enterococcus faecium

Staphylococcus aureus

23S ribosomal RNA

Linezolid

Genetics

Biochemistry

Medicine

Ribosome

Drug Design Development and Therapy

Abstract: Linezolid can be considered as the first member of the class of oxazolidinone antibiotics. The compound is a synthetic antibiotic that inhibits bacterial protein synthesis through binding to rRNA. It also inhibits the creation of the initiation complex during protein synthesis which can reduce the length of the developed peptide chains, and decrease the rate of reaction of translation elongation. Linezolid has been approved for the treatment of infections caused by vancomycin-resistant Enterococcus faecium , hospital-acquired pneumonia caused by Staphylococcus aureus , complicated skin and skin structure infections (SSSIs), uncomplicated SSSIs caused by methicillin-susceptible S . aureus or Streptococcus pyogenes , and community-acquired pneumonia caused by Streptococcus pneumoniae . Analysis of high-resolution structures of linezolid has demonstrated that it binds a deep cleft of the 50S ribosomal subunit that is surrounded by 23S rRNA nucleotides. Mutation of 23S rRNA was shown to be a linezolid resistance mechanism. Besides, mutations in specific regions of ribosomal proteins uL3 and uL4 are increasingly associated with linezolid resistance. However, these proteins are located further away from the bound drug. The methicillin-resistant S . aureus and vancomycin-resistant enterococci are considered the most common Gram-positive bacteria found in intensive care units (ICUs), and linezolid, as an antimicrobial drug, is commonly utilized to treat infected ICU patients. The drug has favorable in vitro and in vivo activity against the mentioned organisms and is considered as a useful antibiotic to treat infections in the ICU. Keywords: linezolid, intensive care unit, MRSA, VRE, antibacterial drugs

Linezolid: a review of its properties, function, and use in critical care