Drug Design Development and Therapy
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#1Qudong LuH-Index: 1
#2Yang YangH-Index: 3
Last. Jingzhen ZhuH-Index: 5
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#1Mahmoud H Teaima (Cairo University)H-Index: 5
#2Rehab Abdelmonem (Misr University for Science and Technology)H-Index: 5
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Purpose The purpose of this study was to prepare telmisartan transethosomes, incorporate them into a gel, evaluate them for in vitro drug release and in vivo permeation using iontophoresis to enhance their transdermal delivery. Materials and Methods TE formulae were prepared using various surfactants (SAAs), different ethanol concentrations, and different phospholipid-to-SAA ratios with different cholesterol ratios, characterized according to their entrapment efficiency percentage (EE%), zeta po...
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#1Sok Kuan Wong (UKM: National University of Malaysia)H-Index: 15
#2Kok-Yong Chin (UKM: National University of Malaysia)H-Index: 25
Last. Soelaiman Ima-Nirwana (UKM: National University of Malaysia)H-Index: 23
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Andrographolide is the major compound found in the medicinal plant, Andrographis paniculata (Burm.f.) Nees, which accounts for its medicinal properties. Both the plant extract and compound have been reported to exhibit potential cardiovascular activities. This review summarises related studies describing the biological activities and target mechanisms of A. paniculata and andrographolide in vivo and in vitro. The current evidence unambiguously indicated the protective effects provided by A. pani...
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#1Meiling Jin (Capital Medical University)
#2Wenwen Ren (Capital Medical University)
Last. Diangeng Li (Capital Medical University)
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Purpose This study aimed to explore the underlying mechanisms of Shenyankangfu tablet (SYKFT) in the treatment of glomerulonephritis (GN) based on network pharmacology, machine learning, molecular docking, and experimental validation. Methods The active ingredients and potential targets of SYKFT were obtained through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, the targets of GN were obtained through GeneCards, etc. Perl and Cytoscape were used to constru...
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