Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs
Abstract
Molecular tools that target RNA at specific sites allow recoding of RNA information and processing. SNAP-tagged deaminases guided by a chemically stabilized guide RNA can edit targeted adenosine to inosine in several endogenous transcripts simultaneously, with high efficiency (up to 90%), high potency, sufficient editing duration, and high precision. We used adenosine deaminases acting on RNA (ADARs) fused to SNAP-tag for the efficient and...
Paper Details
Title
Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs
Published Date
Jul 1, 2018
Journal
Volume
15
Issue
7
Pages
535 - 538
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